Drug interactions
Tacrolimus + Vonoprazan
Severity: Moderate
Tacrolimus and Vonoprazan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan is a weak CYP3A inhibitor and may modestly increase tacrolimus concentrations. Because tacrolimus has a narrow therapeutic range, this may cause toxicity.
What this interaction means in plain words
Tacrolimus and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Weak inhibition of CYP3A-mediated tacrolimus metabolism.
What to do
Check tacrolimus trough levels after starting or stopping vonoprazan and adjust the dose. Monitor renal function and tremor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Tacrolimus with Vonoprazan?
MediHelp rates the interaction as moderate. Tacrolimus and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vonoprazan is a weak CYP3A inhibitor and may modestly increase tacrolimus concentrations. Because tacrolimus has a narrow therapeutic range, this may cause toxicity.
How serious is the interaction between Tacrolimus and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check tacrolimus trough levels after starting or stopping vonoprazan and adjust the dose. Monitor renal function and tremor.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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