Drug interactions
Tafamidis + Topotecan
Severity: Minor
Tafamidis and Topotecan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafamidis inhibits BCRP in vitro and may increase exposure to BCRP substrates such as topotecan. The effect on topotecan has not been well characterized, but higher levels could increase myelosuppression.
What this interaction means in plain words
Tafamidis and Topotecan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tafamidis belongs to Cardiovascular; Topotecan belongs to Oncology.
Why it happens
Tafamidis inhibits BCRP, which can reduce topotecan efflux.
What to do
Monitor blood counts during topotecan therapy and lower the topotecan dose if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Other interactions of Tafamidis
- Apixaban + Tafamidis Moderate
- Atorvastatin + Tafamidis Moderate
- Methotrexate + Tafamidis Moderate
- Mitoxantrone + Tafamidis Moderate
- Pitavastatin + Tafamidis Moderate
- Rivaroxaban + Tafamidis Moderate
Frequently asked questions
Can I take Tafamidis with Topotecan?
MediHelp rates the interaction as minor. Tafamidis and Topotecan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tafamidis inhibits BCRP in vitro and may increase exposure to BCRP substrates such as topotecan. The effect on topotecan has not been well characterized, but higher levels could increase myelosuppression.
How serious is the interaction between Tafamidis and Topotecan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts during topotecan therapy and lower the topotecan dose if toxicity occurs.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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