Drug interactions
Talquetamab + Valproic acid
Severity: Minor
Talquetamab and Valproic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release syndrome from talquetamab can transiently suppress CYP enzymes, but valproate has limited CYP-dependent clearance, so exposure changes are likely small. Valproate can cause thrombocytopenia and hepatotoxicity, which may complicate management of the cytopenias and liver effects seen with talquetamab.
What this interaction means in plain words
Talquetamab and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Talquetamab belongs to Oncology; Valproic acid belongs to Central Nervous System.
Why it happens
Cytokine-mediated CYP suppression of minor relevance to valproate.
What to do
Monitor valproate levels, liver tests and blood counts during step-up dosing and any cytokine release syndrome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Talquetamab with Valproic acid?
MediHelp rates the interaction as minor. Talquetamab and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cytokine release syndrome from talquetamab can transiently suppress CYP enzymes, but valproate has limited CYP-dependent clearance, so exposure changes are likely small. Valproate can cause thrombocytopenia and hepatotoxicity, which may complicate management of the cytopenias and liver effects seen with talquetamab.
How serious is the interaction between Talquetamab and Valproic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor valproate levels, liver tests and blood counts during step-up dosing and any cytokine release syndrome.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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