Drug interactions
Talquetamab + Warfarin
Severity: Moderate
Talquetamab and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talquetamab causes cytokine release, which can transiently suppress CYP enzyme activity. This may raise exposure to warfarin and increase the INR, with bleeding risk. The risk is highest during step-up dosing and around cytokine release syndrome episodes.
What this interaction means in plain words
Talquetamab and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Talquetamab belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
Cytokine-mediated suppression of CYP enzymes (including CYP2C9) reduces warfarin clearance.
What to do
Monitor INR more frequently during step-up dosing and for about two weeks after the first treatment dose, and during any cytokine release syndrome. Adjust the warfarin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Talquetamab with Warfarin?
MediHelp rates the interaction as moderate. Talquetamab and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talquetamab causes cytokine release, which can transiently suppress CYP enzyme activity. This may raise exposure to warfarin and increase the INR, with bleeding risk. The risk is highest during step-up dosing and around cytokine release syndrome episodes.
How serious is the interaction between Talquetamab and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently during step-up dosing and for about two weeks after the first treatment dose, and during any cytokine release syndrome. Adjust the warfarin dose as needed.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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