Drug interactions
Tapentadol + Tranylcypromine
Severity: Contraindicated
Tapentadol and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranylcypromine is an irreversible MAO inhibitor, and with tapentadol it can cause hypertensive crisis, serotonin syndrome and hyperthermia. Tapentadol is contraindicated during and for 14 days after MAOI therapy.
What this interaction means in plain words
Tapentadol and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Tapentadol belongs to Musculoskeletal; Tranylcypromine belongs to Central Nervous System.
Why it happens
Irreversible MAO inhibition plus tapentadol's norepinephrine reuptake inhibition causes excess monoamine activity.
What to do
Do not coadminister, and allow at least 14 days between stopping tranylcypromine and starting tapentadol. Use a non-interacting analgesic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Tapentadol with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Tapentadol and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tranylcypromine is an irreversible MAO inhibitor, and with tapentadol it can cause hypertensive crisis, serotonin syndrome and hyperthermia. Tapentadol is contraindicated during and for 14 days after MAOI therapy.
How serious is the interaction between Tapentadol and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister, and allow at least 14 days between stopping tranylcypromine and starting tapentadol. Use a non-interacting analgesic.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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