Drug interactions
Tapentadol + Ziprasidone
Severity: Moderate
Tapentadol and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Co-administration can increase drowsiness, dizziness and impaired coordination, with possible respiratory depression at high doses. Ziprasidone also prolongs the QT interval, which is not affected by tapentadol but merits attention.
What this interaction means in plain words
Tapentadol and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tapentadol belongs to Musculoskeletal; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from opioid agonism and antipsychotic receptor blockade.
What to do
Use the lowest effective doses and monitor for sedation and orthostasis. Follow ziprasidone QT precautions including electrolyte correction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Tapentadol with Ziprasidone?
MediHelp rates the interaction as moderate. Tapentadol and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Co-administration can increase drowsiness, dizziness and impaired coordination, with possible respiratory depression at high doses. Ziprasidone also prolongs the QT interval, which is not affected by tapentadol but merits attention.
How serious is the interaction between Tapentadol and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and orthostasis. Follow ziprasidone QT precautions including electrolyte correction.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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