Drug interactions
Tazemetostat + Ticagrelor
Severity: Moderate
Tazemetostat and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A inducer and may reduce ticagrelor exposure, possibly weakening platelet inhibition. Ticagrelor, a weak CYP3A inhibitor, could modestly raise tazemetostat levels.
What this interaction means in plain words
Tazemetostat and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tazemetostat belongs to Miscellaneous; Ticagrelor belongs to Cardiovascular.
Why it happens
CYP3A4 induction by tazemetostat increases ticagrelor metabolism, with weaker reciprocal inhibition.
What to do
Monitor for reduced antiplatelet effect and ischemic events, and for tazemetostat adverse effects. Consider alternative antiplatelet therapy if concerns arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Tazemetostat with Ticagrelor?
MediHelp rates the interaction as moderate. Tazemetostat and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak-to-moderate CYP3A inducer and may reduce ticagrelor exposure, possibly weakening platelet inhibition. Ticagrelor, a weak CYP3A inhibitor, could modestly raise tazemetostat levels.
How serious is the interaction between Tazemetostat and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antiplatelet effect and ischemic events, and for tazemetostat adverse effects. Consider alternative antiplatelet therapy if concerns arise.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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