Drug interactions
Tazemetostat + Verapamil
Severity: Moderate
Tazemetostat and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is metabolized by CYP3A4, and verapamil is a moderate inhibitor of this enzyme. Concurrent use can increase tazemetostat exposure and the risk of its adverse effects.
What this interaction means in plain words
Tazemetostat and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tazemetostat belongs to Miscellaneous; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4 and reduces tazemetostat clearance.
What to do
Prefer an alternative to verapamil. If it cannot be avoided, reduce the tazemetostat dose per labeling and monitor for toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Tazemetostat with Verapamil?
MediHelp rates the interaction as moderate. Tazemetostat and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is metabolized by CYP3A4, and verapamil is a moderate inhibitor of this enzyme. Concurrent use can increase tazemetostat exposure and the risk of its adverse effects.
How serious is the interaction between Tazemetostat and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to verapamil. If it cannot be avoided, reduce the tazemetostat dose per labeling and monitor for toxicity.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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