Drug interactions
Tazemetostat + Vinblastine
Severity: Minor
Tazemetostat and Vinblastine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer and could modestly lower vinblastine exposure. Vinblastine is not a recognised CYP3A4 inhibitor, so the reverse effect is unlikely to matter.
What this interaction means in plain words
Tazemetostat and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tazemetostat belongs to Miscellaneous; Vinblastine belongs to Oncology.
Why it happens
Tazemetostat induces CYP3A4, which may modestly increase vinblastine metabolism.
What to do
No dose adjustment is generally needed; monitor for therapeutic response to vinblastine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinblastine
Other interactions of Tazemetostat
Frequently asked questions
Can I take Tazemetostat with Vinblastine?
MediHelp rates the interaction as minor. Tazemetostat and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak-to-moderate CYP3A4 inducer and could modestly lower vinblastine exposure. Vinblastine is not a recognised CYP3A4 inhibitor, so the reverse effect is unlikely to matter.
How serious is the interaction between Tazemetostat and Vinblastine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor for therapeutic response to vinblastine.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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