Drug interactions
Tazemetostat + Zafirlukast
Severity: Moderate
Tazemetostat and Zafirlukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is cleared mainly by CYP3A4, and inhibitors raise its exposure. Zafirlukast is a weak inhibitor, so a modest increase and greater adverse effects such as cytopenias are possible.
What this interaction means in plain words
Tazemetostat and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tazemetostat belongs to Miscellaneous; Zafirlukast belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition by zafirlukast may reduce tazemetostat clearance.
What to do
Monitor blood counts and tolerability. Reduce the tazemetostat dose if adverse reactions develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Tazemetostat
Frequently asked questions
Can I take Tazemetostat with Zafirlukast?
MediHelp rates the interaction as moderate. Tazemetostat and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is cleared mainly by CYP3A4, and inhibitors raise its exposure. Zafirlukast is a weak inhibitor, so a modest increase and greater adverse effects such as cytopenias are possible.
How serious is the interaction between Tazemetostat and Zafirlukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and tolerability. Reduce the tazemetostat dose if adverse reactions develop.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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