Drug interactions
Teclistamab + Theophylline
Severity: Moderate
Teclistamab and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teclistamab triggers cytokine release that can temporarily suppress CYP enzymes, raising exposure to substrates like theophylline. Elevated levels risk toxicity including tachyarrhythmias and seizures, particularly around step-up dosing and CRS episodes.
What this interaction means in plain words
Teclistamab and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Teclistamab belongs to Oncology; Theophylline belongs to Respiratory.
Why it happens
Cytokine-mediated downregulation of CYP1A2 and CYP3A4 lowers theophylline clearance.
What to do
Monitor theophylline levels and signs of toxicity during the first weeks of teclistamab and during CRS; reduce the theophylline dose if concentrations rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Teclistamab
- Pimozide + Teclistamab Major
- Carbamazepine + Teclistamab Moderate
- Colchicine + Teclistamab Moderate
- Cyclosporin + Teclistamab Moderate
- Divalproex + Teclistamab Moderate
- Ergotamine + Teclistamab Moderate
Frequently asked questions
Can I take Teclistamab with Theophylline?
MediHelp rates the interaction as moderate. Teclistamab and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teclistamab triggers cytokine release that can temporarily suppress CYP enzymes, raising exposure to substrates like theophylline. Elevated levels risk toxicity including tachyarrhythmias and seizures, particularly around step-up dosing and CRS episodes.
How serious is the interaction between Teclistamab and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline levels and signs of toxicity during the first weeks of teclistamab and during CRS; reduce the theophylline dose if concentrations rise.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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