Drug interactions
Teduglutide + Valproic acid
Severity: Moderate
Teduglutide and Valproic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teduglutide improves intestinal fluid and nutrient absorption and may increase absorption of oral drugs. Valproate has a narrow therapeutic window, so higher absorption could raise levels and cause toxicity.
What this interaction means in plain words
Teduglutide and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Teduglutide belongs to Endocrine; Valproic acid belongs to Central Nervous System.
Why it happens
Enhanced intestinal absorption of orally administered valproate.
What to do
Check valproate serum concentrations after starting teduglutide and adjust the dose as needed. Monitor for sedation, tremor and nausea.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Teduglutide
- Chlordiazepoxide + Teduglutide Moderate
- Clonazepam + Teduglutide Moderate
- Colchicine + Teduglutide Moderate
- Cyclosporin + Teduglutide Moderate
- Digoxin + Teduglutide Moderate
- Ethosuximide + Teduglutide Moderate
Frequently asked questions
Can I take Teduglutide with Valproic acid?
MediHelp rates the interaction as moderate. Teduglutide and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teduglutide improves intestinal fluid and nutrient absorption and may increase absorption of oral drugs. Valproate has a narrow therapeutic window, so higher absorption could raise levels and cause toxicity.
How serious is the interaction between Teduglutide and Valproic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check valproate serum concentrations after starting teduglutide and adjust the dose as needed. Monitor for sedation, tremor and nausea.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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