Drug interactions
Telavancin + Trazodone
Severity: Moderate
Telavancin and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone can prolong the QTc interval and has been linked to arrhythmias, particularly with other risk factors. Added to telavancin, it may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Telavancin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Telavancin belongs to Anti Bacterial; Trazodone belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes during co-therapy. Consider reducing the trazodone dose or choosing an alternative if QTc rises substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Telavancin with Trazodone?
MediHelp rates the interaction as moderate. Telavancin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone can prolong the QTc interval and has been linked to arrhythmias, particularly with other risk factors. Added to telavancin, it may increase the risk of ventricular arrhythmia.
How serious is the interaction between Telavancin and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes during co-therapy. Consider reducing the trazodone dose or choosing an alternative if QTc rises substantially.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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