Drug interactions
Telavancin + Trimipramine
Severity: Moderate
Telavancin and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine, a tricyclic antidepressant, can prolong the QTc interval and impair conduction. With telavancin the arrhythmia risk may rise, especially in patients with cardiac disease.
What this interaction means in plain words
Telavancin and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Telavancin belongs to Anti Bacterial; Trimipramine belongs to Central Nervous System.
Why it happens
Additive effects on ventricular repolarization and conduction.
What to do
Check a baseline ECG and monitor QTc and electrolytes during co-therapy. Prefer an alternative antibiotic in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Telavancin with Trimipramine?
MediHelp rates the interaction as moderate. Telavancin and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine, a tricyclic antidepressant, can prolong the QTc interval and impair conduction. With telavancin the arrhythmia risk may rise, especially in patients with cardiac disease.
How serious is the interaction between Telavancin and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor QTc and electrolytes during co-therapy. Prefer an alternative antibiotic in patients with QT risk factors.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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