Drug interactions
Temazepam + Thioridazine
Severity: Moderate
Temazepam and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Co-use of a benzodiazepine hypnotic with a sedating phenothiazine increases drowsiness, impaired coordination and fall risk. Respiratory depression is more likely in older or frail patients.
What this interaction means in plain words
Temazepam and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Temazepam belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression via GABA-A potentiation and antihistamine and alpha-blocking effects.
What to do
Use the lowest effective doses and warn patients about impaired driving and alcohol. Monitor sedation, particularly in the elderly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Temazepam with Thioridazine?
MediHelp rates the interaction as moderate. Temazepam and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Co-use of a benzodiazepine hypnotic with a sedating phenothiazine increases drowsiness, impaired coordination and fall risk. Respiratory depression is more likely in older or frail patients.
How serious is the interaction between Temazepam and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn patients about impaired driving and alcohol. Monitor sedation, particularly in the elderly.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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