Drug interactions
Temazepam + Ziprasidone
Severity: Moderate
Temazepam and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temazepam is a benzodiazepine hypnotic, and combined with ziprasidone it can increase drowsiness, dizziness and impaired coordination. Falls and next-day impairment are particular concerns in older adults.
What this interaction means in plain words
Temazepam and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Temazepam belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and the sedating receptor effects of ziprasidone.
What to do
Use the lowest effective doses and monitor for oversedation and orthostatic symptoms. Counsel on avoiding driving after dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Temazepam with Ziprasidone?
MediHelp rates the interaction as moderate. Temazepam and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temazepam is a benzodiazepine hypnotic, and combined with ziprasidone it can increase drowsiness, dizziness and impaired coordination. Falls and next-day impairment are particular concerns in older adults.
How serious is the interaction between Temazepam and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and orthostatic symptoms. Counsel on avoiding driving after dosing.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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