Drug interactions
Temozolomide + Trastuzumab
Severity: Moderate
Temozolomide and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab with myelosuppressive chemotherapy has been associated with more frequent neutropenia and febrile neutropenia. Temozolomide can cause delayed marrow suppression, so the combination may raise infection risk.
What this interaction means in plain words
Temozolomide and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Temozolomide belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive neutropenia when trastuzumab is combined with cytotoxic chemotherapy; the exact mechanism is not fully established.
What to do
Monitor neutrophil and platelet counts and assess promptly for fever. Delay or reduce temozolomide if significant neutropenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Temozolomide and Trastuzumab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Temozolomide
Other interactions of Trastuzumab
Frequently asked questions
Can I take Temozolomide with Trastuzumab?
MediHelp rates the interaction as moderate. Temozolomide and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab with myelosuppressive chemotherapy has been associated with more frequent neutropenia and febrile neutropenia. Temozolomide can cause delayed marrow suppression, so the combination may raise infection risk.
How serious is the interaction between Temozolomide and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil and platelet counts and assess promptly for fever. Delay or reduce temozolomide if significant neutropenia occurs.
What other medicines interact with Temozolomide?
MediHelp also lists interactions of Temozolomide with, for example, Adenovirus types 4 and 7 live, Belatacept, Deferiprone. The full list is on the Temozolomide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
