Drug interactions
Temsirolimus + Trandolapril
Severity: Major
Temsirolimus and Trandolapril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus, an mTOR inhibitor, increases the risk of angioedema in patients on ACE inhibitors. Reactions may involve the airway and can be serious.
What this interaction means in plain words
Temsirolimus and Trandolapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Temsirolimus belongs to Oncology; Trandolapril belongs to Cardiovascular.
Why it happens
Both impair bradykinin degradation pathways, leading to bradykinin accumulation.
What to do
Counsel patients to seek urgent care for facial, tongue or throat swelling. Consider an alternative antihypertensive class if angioedema develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Temsirolimus with Trandolapril?
MediHelp rates the interaction as major. Temsirolimus and Trandolapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Temsirolimus, an mTOR inhibitor, increases the risk of angioedema in patients on ACE inhibitors. Reactions may involve the airway and can be serious.
How serious is the interaction between Temsirolimus and Trandolapril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to seek urgent care for facial, tongue or throat swelling. Consider an alternative antihypertensive class if angioedema develops.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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