Drug interactions
Temsirolimus + Trastuzumab
Severity: Moderate
Temsirolimus and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can contribute to infection risk and neutropenia, particularly with myelosuppressive therapy. The combined effect on immune function may be additive.
What this interaction means in plain words
Temsirolimus and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Temsirolimus belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive immunosuppressive and myelosuppressive effects.
What to do
Monitor complete blood counts and signs of infection. Treat infections promptly and manage neutropenia per protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Trastuzumab
Frequently asked questions
Can I take Temsirolimus with Trastuzumab?
MediHelp rates the interaction as moderate. Temsirolimus and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can contribute to infection risk and neutropenia, particularly with myelosuppressive therapy. The combined effect on immune function may be additive.
How serious is the interaction between Temsirolimus and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and signs of infection. Treat infections promptly and manage neutropenia per protocol.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
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