Drug interactions
Tenecteplase + Vortioxetine
Severity: Major
Tenecteplase and Vortioxetine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenecteplase is a thrombolytic with significant bleeding risk, and vortioxetine impairs platelet function, which may add to that risk. Thrombolysis is typically given in emergencies where treatment should proceed.
What this interaction means in plain words
Tenecteplase and Vortioxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tenecteplase belongs to Cardiovascular; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive bleeding tendency: fibrinolysis from tenecteplase plus reduced platelet aggregation from vortioxetine.
What to do
Do not delay indicated thrombolysis, but monitor closely for bleeding, including intracranial and gastrointestinal sites. Review the need for vortioxetine after the acute event.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Tenecteplase
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Tenecteplase Major
- Apixaban + Tenecteplase Major
- Argatroban + Tenecteplase Major
- Dabigatran etexilate + Tenecteplase Major
- Dalteparin + Tenecteplase Major
Frequently asked questions
Can I take Tenecteplase with Vortioxetine?
MediHelp rates the interaction as major. Tenecteplase and Vortioxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tenecteplase is a thrombolytic with significant bleeding risk, and vortioxetine impairs platelet function, which may add to that risk. Thrombolysis is typically given in emergencies where treatment should proceed.
How serious is the interaction between Tenecteplase and Vortioxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not delay indicated thrombolysis, but monitor closely for bleeding, including intracranial and gastrointestinal sites. Review the need for vortioxetine after the acute event.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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