Drug interactions
Tenofovir disoproxil + Tepotinib
Severity: Moderate
Tenofovir disoproxil and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits intestinal P-glycoprotein and may raise exposure to tenofovir disoproxil, which is a P-gp substrate. Higher tenofovir levels could increase the risk of renal and bone toxicity.
What this interaction means in plain words
Tenofovir disoproxil and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tepotinib inhibits P-glycoprotein efflux, increasing absorption and systemic exposure of tenofovir disoproxil.
What to do
Monitor renal function (creatinine clearance, phosphate) during coadministration. Consider an alternative if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Tenofovir disoproxil with Tepotinib?
MediHelp rates the interaction as moderate. Tenofovir disoproxil and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits intestinal P-glycoprotein and may raise exposure to tenofovir disoproxil, which is a P-gp substrate. Higher tenofovir levels could increase the risk of renal and bone toxicity.
How serious is the interaction between Tenofovir disoproxil and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function (creatinine clearance, phosphate) during coadministration. Consider an alternative if renal function declines.
What other medicines interact with Tepotinib?
MediHelp also lists interactions of Tepotinib with, for example, Colchicine, Digoxin, Vincristine. The full list is on the Tepotinib page.
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