Drug interactions
Tenofovir disoproxil + Tucatinib
Severity: Minor
Tenofovir disoproxil and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits P-glycoprotein and may increase absorption of tenofovir disoproxil. Increases are expected to be modest, but tenofovir exposure is relevant to renal safety.
What this interaction means in plain words
Tenofovir disoproxil and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
P-glycoprotein inhibition by tucatinib increases tenofovir absorption.
What to do
Monitor renal function, including creatinine and phosphate, during coadministration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Tenofovir disoproxil with Tucatinib?
MediHelp rates the interaction as minor. Tenofovir disoproxil and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tucatinib inhibits P-glycoprotein and may increase absorption of tenofovir disoproxil. Increases are expected to be modest, but tenofovir exposure is relevant to renal safety.
How serious is the interaction between Tenofovir disoproxil and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, including creatinine and phosphate, during coadministration.
What other medicines interact with Tucatinib?
MediHelp also lists interactions of Tucatinib with, for example, Cisapride, Eletriptan, Ergotamine. The full list is on the Tucatinib page.
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