Drug interactions
Terbinafine + Voriconazole
Severity: Minor
Terbinafine and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole and terbinafine are both metabolized by multiple CYP enzymes, and voriconazole may modestly raise terbinafine exposure. Terbinafine is generally well tolerated, so clinically significant effects are uncommon, though hepatotoxicity is additive in principle.
What this interaction means in plain words
Terbinafine and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Terbinafine belongs to Anti Fungals; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP2C9/3A4 pathways contributing to terbinafine clearance; terbinafine inhibits CYP2D6.
What to do
No dose change is usually needed; monitor liver function tests if the combination is used for prolonged treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Terbinafine with Voriconazole?
MediHelp rates the interaction as minor. Terbinafine and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole and terbinafine are both metabolized by multiple CYP enzymes, and voriconazole may modestly raise terbinafine exposure. Terbinafine is generally well tolerated, so clinically significant effects are uncommon, though hepatotoxicity is additive in principle.
How serious is the interaction between Terbinafine and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor liver function tests if the combination is used for prolonged treatment.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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