Drug interactions
Teriflunomide + Theophylline
Severity: Moderate
Teriflunomide and Theophylline: moderate interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide may modestly reduce exposure to CYP1A2 substrates such as theophylline. This could lessen bronchodilator effect.
What this interaction means in plain words
Teriflunomide and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Teriflunomide belongs to Central Nervous System; Theophylline belongs to Respiratory.
Why it happens
Teriflunomide is a weak inducer of CYP1A2, increasing theophylline metabolism.
What to do
Monitor theophylline concentrations and clinical response and adjust the dose if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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References
- Teriflunomide - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Teriflunomide
Frequently asked questions
Can I take Teriflunomide with Theophylline?
MediHelp rates the interaction as moderate. Teriflunomide and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teriflunomide may modestly reduce exposure to CYP1A2 substrates such as theophylline. This could lessen bronchodilator effect.
How serious is the interaction between Teriflunomide and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline concentrations and clinical response and adjust the dose if levels fall.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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