Drug interactions
Teriflunomide + Thiothixene
Severity: Minor
Teriflunomide and Thiothixene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide is a weak CYP1A2 inducer and could lower thiothixene concentrations, which are partly dependent on CYP1A2 metabolism. This might reduce antipsychotic effectiveness.
What this interaction means in plain words
Teriflunomide and Thiothixene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak induction of CYP1A2 by teriflunomide increases thiothixene metabolism.
What to do
Watch for loss of psychiatric symptom control and adjust the thiothixene dose if symptoms re-emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Teriflunomide
Frequently asked questions
Can I take Teriflunomide with Thiothixene?
MediHelp rates the interaction as minor. Teriflunomide and Thiothixene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide is a weak CYP1A2 inducer and could lower thiothixene concentrations, which are partly dependent on CYP1A2 metabolism. This might reduce antipsychotic effectiveness.
How serious is the interaction between Teriflunomide and Thiothixene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for loss of psychiatric symptom control and adjust the thiothixene dose if symptoms re-emerge.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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