Drug interactions
Teriflunomide + Trifluoperazine
Severity: Minor
Teriflunomide and Trifluoperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide weakly induces CYP1A2 and could reduce trifluoperazine levels, since trifluoperazine is partly cleared through CYP1A2. Loss of antipsychotic effect is possible but unlikely to be large.
What this interaction means in plain words
Teriflunomide and Trifluoperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP1A2 induction by teriflunomide increases trifluoperazine metabolism.
What to do
Monitor psychiatric symptom control and titrate trifluoperazine if response diminishes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Teriflunomide
Frequently asked questions
Can I take Teriflunomide with Trifluoperazine?
MediHelp rates the interaction as minor. Teriflunomide and Trifluoperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide weakly induces CYP1A2 and could reduce trifluoperazine levels, since trifluoperazine is partly cleared through CYP1A2. Loss of antipsychotic effect is possible but unlikely to be large.
How serious is the interaction between Teriflunomide and Trifluoperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric symptom control and titrate trifluoperazine if response diminishes.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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