Drug interactions
Theophylline + Ticlopidine
Severity: Moderate
Theophylline and Ticlopidine: moderate interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine reduces theophylline clearance and raises serum levels, with a reported prolongation of half-life. This can lead to theophylline toxicity with nausea, tremor, tachycardia and seizures.
What this interaction means in plain words
Theophylline and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Theophylline belongs to Respiratory; Ticlopidine belongs to Cardiovascular.
Why it happens
Ticlopidine inhibits hepatic CYP1A2 metabolism of theophylline.
What to do
Monitor theophylline concentrations when ticlopidine is started or stopped and reduce the theophylline dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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References
- Theophylline (Anhydrous) - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Ticlopidine
Frequently asked questions
Can I take Theophylline with Ticlopidine?
MediHelp rates the interaction as moderate. Theophylline and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine reduces theophylline clearance and raises serum levels, with a reported prolongation of half-life. This can lead to theophylline toxicity with nausea, tremor, tachycardia and seizures.
How serious is the interaction between Theophylline and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline concentrations when ticlopidine is started or stopped and reduce the theophylline dose as needed.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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