Drug interactions
Theophylline + Tucatinib
Severity: Moderate
Theophylline and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a CYP3A inhibitor, but CYP3A4 is only a minor clearance route for theophylline. A modest increase in theophylline levels is possible, which matters because of its narrow therapeutic index.
What this interaction means in plain words
Theophylline and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Theophylline belongs to Respiratory; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing a secondary pathway of theophylline metabolism.
What to do
Monitor theophylline serum levels during tucatinib therapy and reduce the dose if concentrations rise or toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Theophylline with Tucatinib?
MediHelp rates the interaction as moderate. Theophylline and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a CYP3A inhibitor, but CYP3A4 is only a minor clearance route for theophylline. A modest increase in theophylline levels is possible, which matters because of its narrow therapeutic index.
How serious is the interaction between Theophylline and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline serum levels during tucatinib therapy and reduce the dose if concentrations rise or toxicity appears.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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