Drug interactions
Thioridazine + Tipranavir
Severity: Contraindicated
Thioridazine and Tipranavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir given with ritonavir inhibits enzymes that metabolize thioridazine and may substantially increase its levels. Higher levels risk QT prolongation and life-threatening arrhythmia, and thioridazine labeling contraindicates inhibitors of its metabolism.
What this interaction means in plain words
Thioridazine and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Thioridazine belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Inhibition of CYP-mediated thioridazine metabolism, mainly through ritonavir-boosted tipranavir.
What to do
Avoid the combination and use an alternative antipsychotic. Check ECG and electrolytes if exposure has occurred.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Thioridazine with Tipranavir?
MediHelp rates the interaction as contraindicated. Thioridazine and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tipranavir given with ritonavir inhibits enzymes that metabolize thioridazine and may substantially increase its levels. Higher levels risk QT prolongation and life-threatening arrhythmia, and thioridazine labeling contraindicates inhibitors of its metabolism.
How serious is the interaction between Thioridazine and Tipranavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antipsychotic. Check ECG and electrolytes if exposure has occurred.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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