Drug interactions
Thioridazine + Vemurafenib
Severity: Major
Thioridazine and Vemurafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can prolong the QT interval and may alter CYP2D6 substrate exposure, which could increase thioridazine levels. Together these effects raise the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Thioridazine and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Thioridazine belongs to Central Nervous System; Vemurafenib belongs to Oncology.
Why it happens
Additive QT prolongation plus possible pharmacokinetic interaction at CYP2D6.
What to do
Avoid the combination and choose an alternative antipsychotic. If unavoidable, monitor ECG and electrolytes frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Thioridazine with Vemurafenib?
MediHelp rates the interaction as major. Thioridazine and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vemurafenib can prolong the QT interval and may alter CYP2D6 substrate exposure, which could increase thioridazine levels. Together these effects raise the risk of serious ventricular arrhythmias.
How serious is the interaction between Thioridazine and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antipsychotic. If unavoidable, monitor ECG and electrolytes frequently.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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