Drug interactions
Thioridazine + Ziconotide
Severity: Moderate
Thioridazine and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide given intrathecally commonly causes sedation, dizziness and confusion, and thioridazine adds to CNS depression. Cognitive impairment and reduced consciousness may be worsened.
What this interaction means in plain words
Thioridazine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Thioridazine belongs to Central Nervous System; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for drowsiness, confusion and reduced alertness, and reduce the dose of one agent if needed. Stop ziconotide if cognitive or psychiatric symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Thioridazine with Ziconotide?
MediHelp rates the interaction as moderate. Thioridazine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide given intrathecally commonly causes sedation, dizziness and confusion, and thioridazine adds to CNS depression. Cognitive impairment and reduced consciousness may be worsened.
How serious is the interaction between Thioridazine and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness, confusion and reduced alertness, and reduce the dose of one agent if needed. Stop ziconotide if cognitive or psychiatric symptoms worsen.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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