Drug interactions
Thiothixene + Vilazodone
Severity: Moderate
Thiothixene and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a serotonergic antidepressant with an antipsychotic may increase the risk of serotonin syndrome and neuroleptic malignant syndrome. Both conditions can be serious and present with altered mental status, rigidity, hyperthermia and autonomic instability.
What this interaction means in plain words
Thiothixene and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity combined with dopamine D2 blockade; the exact mechanism is not fully established.
What to do
Monitor for mental status changes, neuromuscular hyperactivity, fever and rigidity, especially after initiation or dose increases. Stop both drugs and treat supportively if serotonin syndrome or NMS develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Thiothixene with Vilazodone?
MediHelp rates the interaction as moderate. Thiothixene and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a serotonergic antidepressant with an antipsychotic may increase the risk of serotonin syndrome and neuroleptic malignant syndrome. Both conditions can be serious and present with altered mental status, rigidity, hyperthermia and autonomic instability.
How serious is the interaction between Thiothixene and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status changes, neuromuscular hyperactivity, fever and rigidity, especially after initiation or dose increases. Stop both drugs and treat supportively if serotonin syndrome or NMS develops.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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