Drug interactions
Ticlopidine + Tofacitinib
Severity: Moderate
Ticlopidine and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine strongly inhibits CYP2C19, a secondary pathway for tofacitinib, which may raise tofacitinib levels. The effect on its own is modest, but it matters more if a CYP3A4 inhibitor is also given.
What this interaction means in plain words
Ticlopidine and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ticlopidine belongs to Cardiovascular; Tofacitinib belongs to Musculoskeletal.
Why it happens
Ticlopidine inhibits CYP2C19, reducing tofacitinib clearance.
What to do
Monitor for tofacitinib adverse effects such as infection and cytopenias. Reduce the tofacitinib dose if the patient also takes a moderate or strong CYP3A4 inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Ticlopidine
Frequently asked questions
Can I take Ticlopidine with Tofacitinib?
MediHelp rates the interaction as moderate. Ticlopidine and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine strongly inhibits CYP2C19, a secondary pathway for tofacitinib, which may raise tofacitinib levels. The effect on its own is modest, but it matters more if a CYP3A4 inhibitor is also given.
How serious is the interaction between Ticlopidine and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tofacitinib adverse effects such as infection and cytopenias. Reduce the tofacitinib dose if the patient also takes a moderate or strong CYP3A4 inhibitor.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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