Drug interactions
Ticlopidine + Valoctocogene roxaparvovec
Severity: Moderate
Ticlopidine and Valoctocogene roxaparvovec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valoctocogene roxaparvovec is a gene therapy for hemophilia A that commonly causes transaminase elevations. Ticlopidine can rarely cause hepatotoxicity, so combined use may complicate liver monitoring and add to hepatic risk. Ticlopidine's antiplatelet effect also adds to bleeding risk in hemophilia.
What this interaction means in plain words
Ticlopidine and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ticlopidine belongs to Cardiovascular; Valoctocogene roxaparvovec belongs to Miscellaneous.
Why it happens
Additive hepatotoxic potential, plus ticlopidine's antiplatelet effect on bleeding risk.
What to do
Monitor liver enzymes closely after gene therapy and review the need for ticlopidine. Consider an alternative antiplatelet if ALT rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Other interactions of Valoctocogene roxaparvovec
Frequently asked questions
Can I take Ticlopidine with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Ticlopidine and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valoctocogene roxaparvovec is a gene therapy for hemophilia A that commonly causes transaminase elevations. Ticlopidine can rarely cause hepatotoxicity, so combined use may complicate liver monitoring and add to hepatic risk. Ticlopidine's antiplatelet effect also adds to bleeding risk in hemophilia.
How serious is the interaction between Ticlopidine and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely after gene therapy and review the need for ticlopidine. Consider an alternative antiplatelet if ALT rises.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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