Drug interactions
Ticlopidine + Vorapaxar
Severity: Major
Ticlopidine and Vorapaxar: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs inhibit platelet function through different pathways, and combined use substantially raises bleeding risk, including serious bleeding. Vorapaxar labeling advises caution with other antiplatelet agents.
What this interaction means in plain words
Ticlopidine and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive antiplatelet effect via P2Y12 (ticlopidine) and PAR-1 (vorapaxar) inhibition.
What to do
Avoid combination unless clearly indicated; if used, monitor closely for bleeding and hemoglobin. Consider an alternative regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ticlopidine
Frequently asked questions
Can I take Ticlopidine with Vorapaxar?
MediHelp rates the interaction as major. Ticlopidine and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs inhibit platelet function through different pathways, and combined use substantially raises bleeding risk, including serious bleeding. Vorapaxar labeling advises caution with other antiplatelet agents.
How serious is the interaction between Ticlopidine and Vorapaxar?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination unless clearly indicated; if used, monitor closely for bleeding and hemoglobin. Consider an alternative regimen.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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