Drug interactions
Timolol + Tiotropium-olodaterol
Severity: Major
Timolol and Tiotropium-olodaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers such as timolol oppose the bronchodilator effect of olodaterol and can precipitate severe bronchospasm in patients with airway disease. Even ophthalmic timolol can be absorbed enough to cause this in susceptible patients.
What this interaction means in plain words
Timolol and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Timolol belongs to Cardiovascular; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta2 receptors by nonselective beta-blockade.
What to do
Avoid nonselective beta-blockers like timolol in patients with asthma or COPD; if a beta-blocker is necessary, choose a cardioselective agent and monitor respiratory function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tiotropium-olodaterol
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Timolol with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Timolol and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Beta-blockers such as timolol oppose the bronchodilator effect of olodaterol and can precipitate severe bronchospasm in patients with airway disease. Even ophthalmic timolol can be absorbed enough to cause this in susceptible patients.
How serious is the interaction between Timolol and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid nonselective beta-blockers like timolol in patients with asthma or COPD; if a beta-blocker is necessary, choose a cardioselective agent and monitor respiratory function.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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