Drug interactions
Tinidazole + Tipranavir
Severity: Minor
Tinidazole and Tipranavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, has mixed effects on CYP3A4 (net strong inhibition with some induction) and may alter tinidazole concentrations. Higher tinidazole exposure could increase nausea, metallic taste and neurological adverse effects. Clinical data are lacking.
What this interaction means in plain words
Tinidazole and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tinidazole belongs to Anti Parasitic; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir modulates CYP3A4, which contributes to tinidazole metabolism.
What to do
No dose change is routinely needed; monitor for tinidazole adverse effects such as GI upset or neurotoxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Tinidazole with Tipranavir?
MediHelp rates the interaction as minor. Tinidazole and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tipranavir, given with ritonavir, has mixed effects on CYP3A4 (net strong inhibition with some induction) and may alter tinidazole concentrations. Higher tinidazole exposure could increase nausea, metallic taste and neurological adverse effects. Clinical data are lacking.
How serious is the interaction between Tinidazole and Tipranavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor for tinidazole adverse effects such as GI upset or neurotoxicity.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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