Drug interactions
Tiotropium-olodaterol + Tolterodine
Severity: Moderate
Tiotropium-olodaterol and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolterodine is an antimuscarinic and adds to the anticholinergic effects of tiotropium. This can increase dry mouth, constipation, urinary retention, blurred vision and raised intraocular pressure.
What this interaction means in plain words
Tiotropium-olodaterol and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tiotropium-olodaterol belongs to Respiratory; Tolterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic receptor blockade.
What to do
Monitor for anticholinergic adverse effects, especially in older adults or those with glaucoma or urinary retention; reconsider the need for both agents if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Tolterodine
Frequently asked questions
Can I take Tiotropium-olodaterol with Tolterodine?
MediHelp rates the interaction as moderate. Tiotropium-olodaterol and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolterodine is an antimuscarinic and adds to the anticholinergic effects of tiotropium. This can increase dry mouth, constipation, urinary retention, blurred vision and raised intraocular pressure.
How serious is the interaction between Tiotropium-olodaterol and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, especially in older adults or those with glaucoma or urinary retention; reconsider the need for both agents if symptoms occur.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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