Drug interactions
Tiotropium-olodaterol + Vandetanib
Severity: Major
Tiotropium-olodaterol and Vandetanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib markedly prolongs the QT interval and carries a boxed warning for torsades de pointes and sudden death. Olodaterol, a beta2-agonist, can add to cardiac repolarization effects and lower potassium, increasing arrhythmia risk.
What this interaction means in plain words
Tiotropium-olodaterol and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tiotropium-olodaterol belongs to Respiratory; Vandetanib belongs to Oncology.
Why it happens
Additive QT prolongation, with beta2-agonist-induced hypokalemia and sympathetic stimulation increasing proarrhythmic risk.
What to do
Avoid the combination where possible and consider alternative bronchodilators. If unavoidable, monitor ECG, potassium and magnesium at baseline and regularly, and keep electrolytes within normal limits.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tiotropium-olodaterol
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Tiotropium-olodaterol with Vandetanib?
MediHelp rates the interaction as major. Tiotropium-olodaterol and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vandetanib markedly prolongs the QT interval and carries a boxed warning for torsades de pointes and sudden death. Olodaterol, a beta2-agonist, can add to cardiac repolarization effects and lower potassium, increasing arrhythmia risk.
How serious is the interaction between Tiotropium-olodaterol and Vandetanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and consider alternative bronchodilators. If unavoidable, monitor ECG, potassium and magnesium at baseline and regularly, and keep electrolytes within normal limits.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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