Drug interactions
Tipranavir + Tolbutamide
Severity: Moderate
Tipranavir and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir/ritonavir has mixed effects on CYP2C9, and the net effect on tolbutamide exposure is unpredictable. Protease inhibitors can also cause insulin resistance and hyperglycemia, so glucose control may change in either direction.
What this interaction means in plain words
Tipranavir and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tipranavir belongs to Anti Virals; Tolbutamide belongs to Endocrine.
Why it happens
Variable CYP2C9 modulation by tipranavir/ritonavir plus protease-inhibitor-related insulin resistance.
What to do
Monitor blood glucose closely when starting or stopping tipranavir and adjust the tolbutamide dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Tipranavir and Tolbutamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Tipranavir with Tolbutamide?
MediHelp rates the interaction as moderate. Tipranavir and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir/ritonavir has mixed effects on CYP2C9, and the net effect on tolbutamide exposure is unpredictable. Protease inhibitors can also cause insulin resistance and hyperglycemia, so glucose control may change in either direction.
How serious is the interaction between Tipranavir and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping tipranavir and adjust the tolbutamide dose according to response.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
