Drug interactions
Tipranavir + Umeclidinium-vilanterol
Severity: Moderate
Tipranavir and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted tipranavir strongly inhibits CYP3A4 and may raise systemic vilanterol exposure. Beta-agonist cardiovascular effects may be intensified.
What this interaction means in plain words
Tipranavir and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tipranavir belongs to Anti Virals; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP3A4, reducing vilanterol clearance.
What to do
Monitor heart rate, potassium and ECG if symptoms occur; avoid exceeding the recommended dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Tipranavir with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Tipranavir and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted tipranavir strongly inhibits CYP3A4 and may raise systemic vilanterol exposure. Beta-agonist cardiovascular effects may be intensified.
How serious is the interaction between Tipranavir and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, potassium and ECG if symptoms occur; avoid exceeding the recommended dose.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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