Drug interactions
Tipranavir + Verapamil
Severity: Moderate
Tipranavir and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted tipranavir has mixed effects on CYP3A4 and P-glycoprotein, so verapamil concentrations may rise or fall unpredictably. Verapamil may also modestly raise tipranavir levels. Excess verapamil effect can cause bradycardia, AV block and hypotension.
What this interaction means in plain words
Tipranavir and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tipranavir belongs to Anti Virals; Verapamil belongs to Cardiovascular.
Why it happens
Opposing effects of tipranavir on CYP3A4 (inhibition) and P-glycoprotein (induction) alter verapamil exposure.
What to do
Monitor ECG, heart rate and blood pressure when starting or stopping tipranavir, and titrate verapamil to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Tipranavir with Verapamil?
MediHelp rates the interaction as moderate. Tipranavir and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted tipranavir has mixed effects on CYP3A4 and P-glycoprotein, so verapamil concentrations may rise or fall unpredictably. Verapamil may also modestly raise tipranavir levels. Excess verapamil effect can cause bradycardia, AV block and hypotension.
How serious is the interaction between Tipranavir and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and blood pressure when starting or stopping tipranavir, and titrate verapamil to response.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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