Drug interactions
Tipranavir + Vinblastine
Severity: Major
Tipranavir and Vinblastine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir with ritonavir strongly inhibits CYP3A4 and affects P-glycoprotein, which may increase vinblastine exposure. This risks severe myelosuppression, neurotoxicity and ileus.
What this interaction means in plain words
Tipranavir and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tipranavir belongs to Anti Virals; Vinblastine belongs to Oncology.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP3A4 and P-glycoprotein, reducing vinblastine clearance.
What to do
Avoid if possible, or reduce the vinblastine dose with close monitoring of blood counts and neurological and bowel function. Consider another antiretroviral regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Tipranavir and Vinblastine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Vinblastine
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Tipranavir with Vinblastine?
MediHelp rates the interaction as major. Tipranavir and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir with ritonavir strongly inhibits CYP3A4 and affects P-glycoprotein, which may increase vinblastine exposure. This risks severe myelosuppression, neurotoxicity and ileus.
How serious is the interaction between Tipranavir and Vinblastine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or reduce the vinblastine dose with close monitoring of blood counts and neurological and bowel function. Consider another antiretroviral regimen.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
