Drug interactions
Tipranavir + Warfarin
Severity: Major
Tipranavir and Warfarin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted tipranavir has complex effects on drug metabolism and may change warfarin exposure unpredictably. Tipranavir can also impair platelet aggregation and has been linked to intracranial hemorrhage, adding to bleeding risk.
What this interaction means in plain words
Tipranavir and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tipranavir belongs to Anti Virals; Warfarin belongs to Cardiovascular.
Why it happens
Mixed CYP inhibition and induction by tipranavir/ritonavir alters warfarin clearance, with additional antiplatelet effects.
What to do
Monitor INR frequently when starting or stopping tipranavir and adjust the warfarin dose. Watch for bleeding and consider an alternative antiretroviral if control is poor.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Tipranavir with Warfarin?
MediHelp rates the interaction as major. Tipranavir and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir-boosted tipranavir has complex effects on drug metabolism and may change warfarin exposure unpredictably. Tipranavir can also impair platelet aggregation and has been linked to intracranial hemorrhage, adding to bleeding risk.
How serious is the interaction between Tipranavir and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR frequently when starting or stopping tipranavir and adjust the warfarin dose. Watch for bleeding and consider an alternative antiretroviral if control is poor.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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