Drug interactions
Tipranavir + Zidovudine
Severity: Moderate
Tipranavir and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir with ritonavir can lower zidovudine exposure, which may reduce its antiviral effect. Immune reconstitution inflammatory syndrome may also occur after starting effective HIV therapy, though this is not a true interaction.
What this interaction means in plain words
Tipranavir and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tipranavir belongs to Anti Virals; Zidovudine belongs to Anti Virals.
Why it happens
Tipranavir/ritonavir likely induces glucuronidation of zidovudine, increasing its clearance.
What to do
Monitor HIV viral load and CD4 counts; labeling suggests the combination may need to be avoided or used with caution. Watch for new inflammatory symptoms after starting therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Tipranavir with Zidovudine?
MediHelp rates the interaction as moderate. Tipranavir and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir with ritonavir can lower zidovudine exposure, which may reduce its antiviral effect. Immune reconstitution inflammatory syndrome may also occur after starting effective HIV therapy, though this is not a true interaction.
How serious is the interaction between Tipranavir and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and CD4 counts; labeling suggests the combination may need to be avoided or used with caution. Watch for new inflammatory symptoms after starting therapy.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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