Drug interactions
Tirofiban + Vortioxetine
Severity: Moderate
Tirofiban and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine can impair platelet serotonin uptake and modestly raise bleeding risk. With tirofiban, the combined effect on hemostasis may increase bleeding.
What this interaction means in plain words
Tirofiban and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tirofiban belongs to Cardiovascular; Vortioxetine belongs to Central Nervous System.
Why it happens
Reduced platelet serotonin uptake adds to GP IIb/IIIa receptor inhibition.
What to do
Monitor for bleeding and hemoglobin during tirofiban therapy. Reassess the antidepressant if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Tirofiban and Vortioxetine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tirofiban
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Tirofiban with Vortioxetine?
MediHelp rates the interaction as moderate. Tirofiban and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine can impair platelet serotonin uptake and modestly raise bleeding risk. With tirofiban, the combined effect on hemostasis may increase bleeding.
How serious is the interaction between Tirofiban and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and hemoglobin during tirofiban therapy. Reassess the antidepressant if bleeding occurs.
What other medicines interact with Tirofiban?
MediHelp also lists interactions of Tirofiban with, for example, Abrocitinib, Acalabrutinib, Acetylsalicylic acid. The full list is on the Tirofiban page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
