Drug interactions
Tisagenlecleucel + Vedolizumab
Severity: Moderate
Tisagenlecleucel and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tisagenlecleucel is a CD19-directed CAR T-cell therapy given after lymphodepleting chemotherapy, with risk of prolonged cytopenias, B-cell aplasia and serious infection. Vedolizumab may add modestly to infection risk, though its action is largely gut-selective.
What this interaction means in plain words
Tisagenlecleucel and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tisagenlecleucel belongs to Oncology; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunomodulation between gut-selective integrin blockade and CAR T-related immune suppression; largely theoretical.
What to do
Review whether vedolizumab should be held around lymphodepletion and CAR T infusion. Monitor for infection and cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Other interactions of Tisagenlecleucel
Frequently asked questions
Can I take Tisagenlecleucel with Vedolizumab?
MediHelp rates the interaction as moderate. Tisagenlecleucel and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tisagenlecleucel is a CD19-directed CAR T-cell therapy given after lymphodepleting chemotherapy, with risk of prolonged cytopenias, B-cell aplasia and serious infection. Vedolizumab may add modestly to infection risk, though its action is largely gut-selective.
How serious is the interaction between Tisagenlecleucel and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review whether vedolizumab should be held around lymphodepletion and CAR T infusion. Monitor for infection and cytopenias.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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