Drug interactions
Tizanidine + Treprostinil
Severity: Moderate
Tizanidine and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent prostacyclin vasodilator that can cause systemic hypotension, and tizanidine also lowers blood pressure. Combined use may lead to additive hypotension, dizziness and syncope.
What this interaction means in plain words
Tizanidine and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tizanidine belongs to Musculoskeletal; Treprostinil belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotension from prostacyclin-mediated vasodilation and central alpha-2 agonism.
What to do
Monitor blood pressure and symptoms of hypotension when starting or adjusting either drug. Use the lowest effective tizanidine dose and reduce treprostinil titration speed if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Tizanidine with Treprostinil?
MediHelp rates the interaction as moderate. Tizanidine and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent prostacyclin vasodilator that can cause systemic hypotension, and tizanidine also lowers blood pressure. Combined use may lead to additive hypotension, dizziness and syncope.
How serious is the interaction between Tizanidine and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or adjusting either drug. Use the lowest effective tizanidine dose and reduce treprostinil titration speed if hypotension occurs.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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