Drug interactions
Tolfenamic acid + Torsemide
Severity: Moderate
Tolfenamic acid and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolfenamic acid can blunt the diuretic and antihypertensive effect of loop diuretics. They may also cause sodium retention and, in volume-depleted patients, acute kidney injury.
What this interaction means in plain words
Tolfenamic acid and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolfenamic acid belongs to Musculoskeletal; Torsemide belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, antagonizing loop diuretic action.
What to do
Use the lowest effective NSAID dose for the shortest time and monitor blood pressure, weight, edema and renal function. Consider a non-NSAID analgesic in heart failure or renal disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Torsemide
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Tolfenamic acid with Torsemide?
MediHelp rates the interaction as moderate. Tolfenamic acid and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as tolfenamic acid can blunt the diuretic and antihypertensive effect of loop diuretics. They may also cause sodium retention and, in volume-depleted patients, acute kidney injury.
How serious is the interaction between Tolfenamic acid and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and monitor blood pressure, weight, edema and renal function. Consider a non-NSAID analgesic in heart failure or renal disease.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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