Drug interactions
Tolmetin + Trazodone
Severity: Moderate
Tolmetin and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has serotonergic activity that can impair platelet function, and combined with an NSAID it may increase the risk of gastrointestinal bleeding. The risk is smaller than with potent SSRIs but is still relevant in high-risk patients.
What this interaction means in plain words
Tolmetin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolmetin belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Additive effects on platelet aggregation (serotonin reuptake inhibition plus COX inhibition) together with NSAID mucosal injury.
What to do
Monitor for signs of GI bleeding and consider a proton pump inhibitor in older or high-risk patients. Use the lowest effective tolmetin dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Tolmetin with Trazodone?
MediHelp rates the interaction as moderate. Tolmetin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone has serotonergic activity that can impair platelet function, and combined with an NSAID it may increase the risk of gastrointestinal bleeding. The risk is smaller than with potent SSRIs but is still relevant in high-risk patients.
How serious is the interaction between Tolmetin and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and consider a proton pump inhibitor in older or high-risk patients. Use the lowest effective tolmetin dose for the shortest time.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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